Discussions of socioeconomic liability and compensation must necessarily start from an understanding of the socioeconomic, legal, and scientific basis for identifying, assessing, managing, and apportioning blame for hazards related to innovations. Public discussions about the nature of the liability challenge related to genetically modified (GM) crops and other modified organisms have focused less on direct, traditional health, public safety, technical, or environmental failures (e.g., innovations that generate hazards directly for users or indirectly to bystanders) and more on socioeconomic concerns, such (...) as comingled product that offends product quality standards. This article examines the theoretical and legal underpinnings of the current risk analysis framework used in most Organization for Economic Cooperation and Development countries and uses it to assess two areas of significant controversy—the release of herbicide-tolerant canola and flax varieties in Western Canada. The article offers lessons for the management of liabilities arising from the introduction of GM crops. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

We take up the challenge of developing an international network with capacity to survey the world’s scientists on an ongoing basis, providing rich datasets regarding the opinions of scientists and scientific sub-communities, both at a time and also over time. The novel methodology employed sees local coordinators, at each institution in the network, sending survey invitation emails internally to scientists at their home institution. The emails link to a ‘10 second survey’, where the participant is presented with a single statement (...) to consider, and a standard five-point Likert scale. In June 2023, a group of 30 philosophers and social scientists invited 20,085 scientists across 30 institutions in 12 countries to participate, gathering 6,807 responses to the statement Science has put it beyond reasonable doubt that COVID-19 is caused by a virus. The study demonstrates that it is possible to establish a global network to quickly ascertain scientific opinion on a large international scale, with high response rate, low opt-out rate, and in a way that allows for significant (perhaps indefinite) repeatability. Measuring scientific opinion in this new way would be a valuable complement to currently available approaches, potentially informing policy decisions and public understanding across diverse fields. (shrink)

We take up the challenge of developing an international network with capacity to survey the world's scientists on an ongoing basis, providing rich datasets regarding the opinions of scientists and scientific sub-communities, both at a time and also over time. The novel methodology employed sees local coordinators, at each institution in the network, sending survey invitation emails internally to scientists at their home institution. The emails link to a ‘10 second survey’, where the participant is presented with a single statement (...) to consider, and a standard five point Likert scale. In June 2023, a group of 30 philosophers and social scientists invited 20,085 scientists across 30 institutions in 12 countries to participate, gathering 6,807 responses to the statement 'Science has put it beyond reasonable doubt that COVID-19 is caused by a virus'. The study demonstrates that it is possible to establish a global network to quickly ascertain scientific opinion on a large international scale, with high response rate, low opt-out rate, and in a way that allows for significant (perhaps indefinite) repeatability. Measuring scientific opinion in this new way would be a valuable complement to currently available approaches, potentially informing policy decisions and public understanding across diverse fields. (shrink)

We take up the challenge of developing an international network with capacity to survey the world’s scientists on an ongoing basis, providing rich datasets regarding the opinions of scientists and scientific sub-communities, both at a time and also over time. The novel methodology employed sees local coordinators, at each institution in the network, sending survey invitation emails internally to scientists at their home institution. The emails link to a ‘10 second survey’, where the participant is presented with a single statement (...) to consider, and a standard five-point Likert scale. In June 2023, a group of 30 philosophers and social scientists invited 20,085 scientists across 30 institutions in 12 countries to participate, gathering 6,807 responses to the statement Science has put it beyond reasonable doubt that COVID-19 is caused by a virus. The study demonstrates that it is possible to establish a global network to quickly ascertain scientific opinion on a large international scale, with high response rate, low opt-out rate, and in a way that allows for significant (perhaps indefinite) repeatability. Measuring scientific opinion in this new way would be a valuable complement to currently available approaches, potentially informing policy decisions and public understanding across diverse fields. (shrink)

Foundational attitudes towards quantum theory have recently thrown off much of the old philosophical baggage largely associated with Niels Bohr to which Einstein famously objected, including the central ‘collapse of the wavefunction’ concept. A ‘neo-Copenhagen’ interpretation, it is suggested, has arisen. This development is placed in its historical context and contrasted to philosophical allegations of anti-realism. The neo-Copenhagen interpretation remains wedded to Heisenberg's uncertainty and observer-dependent values of particles. However a discussion of Nick Herbert's ‘rainbow analogy’ suggests that subatomic particles (...) are emergent from a ‘nonlocal’ level of reality outside the domain of space and time. Critical realism recognizes that emergent systems have an irreducibly ontologically character, and in its combination of epistemological relativism and ontological realism, provides a basis for the proposition that realists who support Einstein's objections must now recognize that their realism must be redefined. (shrink)

BackgroundCentral to ethically justified clinical trial design is the need for an informed consent process responsive to how potential subjects actually comprehend study participation, especially study goals, risks, and potential benefits. This will be particularly challenging when studying deep brain stimulation and whether it impedes symptom progression in Parkinson’s disease, since potential subjects will be Parkinson’s patients for whom deep brain stimulation will likely have therapeutic value in the future as their disease progresses.MethodAs part of an expanded informed consent process (...) for a pilot Phase I study of deep brain stimulation in early stage Parkinson’s disease, an ethics questionnaire composed of 13 open-ended questions was distributed to potential subjects. The questionnaire was designed to guide potential subjects in thinking about their potential participation.ResultsWhile the purpose of the study (safety and tolerability) was extensively presented during the informed consent process, in returned responses 70 percent focused on effectiveness and 91 percent included personal benefit as potential benefit from enrolling. However, 91 percent also indicated helping other Parkinson’s patients as motivation when considering whether or not to enroll.ConclusionsThis combination of responses highlights two issues to which investigators need to pay close attention in future trial designs: (1) how, and in what ways, informed consent processes reinforce potential subjects’ preconceived understandings of benefit, and (2) that potential subjects see themselves as part of a community of Parkinson’s sufferers with responsibilities extending beyond self-interest. More importantly, it invites speculation that a different paradigm for informed consent may be needed. (shrink)

This article examines the intersection of two drivers in the contemporary higher education environment. First, the increase in blended learning, propelled by advances in computing technology and the drive towards student-centred, active learning pedagogies influenced by social constructivism. Second, the need for university curriculum to become more inclusive as the sector continues to respond to the social justice and business aspects of the widening participation agenda. In response to this need for effectively designed blended pedagogies in technology-rich physical and online (...) environments and the need to design for inclusion, this article argues for the adoption of the principles of Universal Design for Learning to be used in curriculum design and development. Not only is an implementation of Universal Design for Learning easier in a technology-rich learning environment, it is the ethical responsibility of universities to provide accessible curriculum as they seek to attract and retain more students through pathways and equity programs. (shrink)

ObjectivesTo describe reporting of informed consent in pragmatic trials, justifications for waivers of consent and reporting of alternative approaches to standard written consent. To identify factors associated with (1) not reporting and (2) not obtaining consent.MethodsSurvey of primary trial reports, published 2014–2019, identified using an electronic search filter for pragmatic trials implemented in MEDLINE, and registered in ClinicalTrials.gov.ResultsAmong 1988 trials, 132 (6.6%) did not include a statement about participant consent, 1691 (85.0%) reported consent had been obtained, 139 (7.0%) reported a (...) waiver and 26 (1.3%) reported consent for one aspect (eg, data collection) but a waiver for another (eg, intervention). Of the 165 trials reporting a waiver, 76 (46.1%) provided a justification. Few (53, 2.9%) explicitly reported use of alternative approaches to consent. In multivariable logistic regression analyses, lower journal impact factor (p=0.001) and cluster randomisation (p<0.0001) were significantly associated with not reporting on consent, while trial recency, cluster randomisation, higher-income country settings, health services research and explicit labelling as pragmatic were significantly associated with not obtaining consent (all p<0.0001).DiscussionNot obtaining consent seems to be increasing and is associated with the use of cluster randomisation and pragmatic aims, but neither cluster randomisation nor pragmatism are currently accepted justifications for waivers of consent. Rather than considering either standard written informed consent or waivers of consent, researchers and research ethics committees could consider alternative consent approaches that may facilitate the conduct of pragmatic trials while preserving patient autonomy and the public’s trust in research. (shrink)

A discussion of the future of interdisciplinary research.

From the late nineteenth to twentieth century, the Bhagavad-Gītā became a transnational text influenced and molded by British colonialism and Orientalism. In this article, I argue that a particularly influential western figure, Peter Brook, adapted and represented the Gītā for a transnational audience in ways that expanded a neocolonial and Orientalist interpretive horizon for its contemporary reception. This essay examines how Brook’s particular approach to and universalist representation of the Gītā reveal an important decolonial paradox: the extension of colonial relations (...) into artistic and scholarly exchanges when attempting to enhance a text’s cross-cultural intelligibility. I advance this argument by critically exploring Brook’s universalist claims and ethical reflections on war, showing how his neocolonial vision of order—along with his impulse for control and speedy consumption of “performance capital”—ultimately undercut his universalizing aspirations. Finally, this examination elucidates a positive strategy for addressing the decolonial paradox in a contemporary Indian setting. (shrink)

John Stuart Mill was born two hundred years ago, on 20 th May, 1806. He died on 7 th May 1873. Peter Cave brings to life some of the thinking of this outstanding philosopher.

L’utilitarisme de Bentham transforme profondément la doctrine antérieure de la liberté de parole en la mettant au service de la recherche de la vérité et en réfléchissant à la portée du contrôle exercé par le gouvernement. Il préserve la distinction entre les affirmations portant sur des opinions et celles portant sur des faits et accorde aux premières une moindre protection. Comme l’avait fait son père James Mill, John Stuart Mill conserve cette distinction dans ses écrits de jeunesse mais ces (...) analyses souffrent de faiblesses logiques et de naïveté politique. Dans De la liberté, John Stuart Mill cherche à dépasser ces difficultés et propose une nouvelle défense de la liberté d’expression en tant que liberté de délibération. Contrairement à la plupart des interprétations, cet article démontre que cette nouvelle approche ne remet pas en cause la distinction fondamentale entre l’expression des opinions (qui sont protégées de façon absolue) et les affirmations portant sur des faits, qui ne sont protégées que de façon contingente, ce qui laisse ouverte la possibilité de restreindre l’expression d’affirmations fausses portant sur des faits. (shrink)

This is a review of Arnon Levy and Peter Godfrey-Smith's book, The Scientific Imagination.

In three exemplary essays, author Peter Bornedal promotes Deconstruction as a cogent analytical method whose distinctive critical object is foundational knowledge. In this, he wants to restore Deconstruction as a rational discourse, while continuing to emphasize it as a critique of metaphysics.

Peter Railton (1978) has introduced the influential deductive-nomological-probabilistic (DNP) model of explanation which is the culmination of a tradition of formal, non-pragmatic accounts of scientific explanation. The other models in this tradition have been shown to be susceptible to a class of counterexamples involving intervening causes which speak against their sufficiency. This treatment has never been extended to the DNP model; we contend that the usual form of these counterexamples is ineffective in this case. However, we develop below a new (...) version which overcomes these difficulties. Thus we claim that all of the models in this tradition, DNP included, have an equal status with respect to sufficiency. (shrink)

Gómez Pereira's _Antoniana Margarita_ represents one of the most original works of his time. Its author develops some issues of great impact in later philosophy, such as animal automatism, soul-body radical separation and self-awareness.

Systematic semantic ambiguities result from the interaction of the two operations that are involved in resolving ellipsis in the presence of scoping elements such as quantifiers and intensional operators: scope determination for the scoping elements and resolution of the elided relation. A variety of problematic examples previously noted - by Sag, Hirschbüihler, Gawron and Peters, Harper, and others - all have to do with such interactions. In previous work, we showed how ellipsis resolution can be stated and solved in (...) equational terms. Furthermore, this equational analysis of ellipsis provides a uniform framework in which interactions between ellipsis resolution and scope determination can be captured. As a consequence, an account of the problematic examples follows directly from the equational method. The goal of this paper is merely to point out this pleasant aspect of the equational analysis, through its application to these cases. No new analytical methods or associated formalism are presented, with the exception of a straightforward extension of the equational method to intensional logic. (shrink)

This paper defends the Famine Relief Argument against Having Children, which goes as follows: conceiving and raising a child costs hundreds of thousands of dollars; that money would be far better spent on famine relief; therefore, conceiving and raising children is immoral. It is named after Peter Singer’s Famine Relief Argument because it might be a special case of Singer’s argument and because it exposes the main practical implication of Singer’s argument—namely, that we should not become parents. I answer five (...) objections: that disaster would ensue if nobody had children; that having children cannot be wrong because it is so natural for human beings; that the argument demands too much of us; that my child might be a great benefactor to the world; and that we should raise our children frugally and give them the right values rather than not have them. Previous arguments against procreation have appealed either to a pessimism about human life, or to the environmental impact of overpopulation, or to the fact that we cannot obtain the consent of the non-existent. The argument proposed here appeals to the severe opportunity costs of parenting. (shrink)

In The Ethics of Food, Gregory E. Pence brings together a collection of voices who share the view that the ethics of genetically modified food is among the most pressing societal questions of our time. This comprehensive collection addresses a broad range of subjects, including the meaning of food, moral analyses of vegetarianism and starvation, the safety and environmental risks of genetically modified food, issues of global food politics and the food industry, and the relationships among food, evolution, and human (...) history. (shrink)

Peter Sloterdijk is one of the most challenging and contentious thinkers currently working within the European tradition. This is the first collection devoted to his work for English-language audiences and will act as an introduction to his work, set an agenda for engagement with his ideas, and relate his writings to a range of political, theoretical and practical contexts. -/- Since his philosophical bestseller Critique of Cynical Reason (1983), Sloterdijk has exercised an important influence over German and other European thought (...) and recently interest in his diverse oeuvre has grown considerably. The past few years have seen a number of his books translated into English, with many more to come. The book seeks to do justice to the breadth of Sloterdijk’s work throughout his career, orientated around the central topics of cynicism, ressentiment, the posthuman, space and world, art and literature, language, social science and his role as a public intellectual. Contributors include Babette Babich, Sjoerd van Tuinen, Eduardo Mendieta, Marie-Eve Morin, Efrain Kristol, Wieland Hoban, Nigel Thrift, Jean-Pierre Couture, and Sloterdijk himself. -/- An explicitly interdisciplinary project, Sloterdijk Now is a crucial introduction to the work of this central thinker, in its complexity, variety and notoriety. It is set to spark debate amongst students and scholars across the humanities and social sciences. (shrink)

This book introduces students and practitioners to important ethical concepts through the lives of major thinkers ranging from Aristotle to Ayn Rand, John Stuart Mill to the Dalai Lama.

John Stuart Mill's philosophy contains an important ‘radical’ dimension, deriving from his early exposure to the philosophies of Jeremy Bentham and of his father, James Mill. In this chapter, I argue that the doctrine Mill termed ‘philosophic radicalism’ is best understood as an attempt to initiate political reform by introducing radically democratic institutions, avoiding narrowly ‘sectarian’ assumptions about utility and social theory. Contrasting Mill's understanding of philosophic radicalism with Bentham's early and late democratic theory, I show that philosophic radicalism (...) characterized by its critique of ‘aristocratic’ privilege and the corresponding aim to uproot it, but also by commitments of varying intensity to the extension of the franchise, to public and parliamentary deliberation, and to the ‘omnicompetence’ of democratic legislation. (shrink)

This paper is a review of work on Newman's objection to epistemic structural realism (ESR). In Section 2, a brief statement of ESR is provided. In Section 3, Newman's objection and its recent variants are outlined. In Section 4, two responses that argue that the objection can be evaded by abandoning the Ramsey-sentence approach to ESR are considered. In Section 5, three responses that have been put forward specifically to rescue the Ramsey-sentence approach to ESR from the modern versions of (...) the objection are discussed. Finally, in Section 6, three responses are considered that are neutral with respect to one's approach to ESR and all argue (in different ways) that the objection can be evaded by introducing the notion that some relations/structures are privileged over others. It is concluded that none of these suggestions is an adequate response to Newman's objection, which therefore remains a serious problem for ESRists. Introduction Epistemic Structural Realism 2.1 Ramsey-sentences and ESR 2.2 WESR and SESR The Objection 3.1 Newman's version 3.2 Demopoulos and Friedman's and Ketland's versions Replies that Abandon the Ramsey-Sentence Approach to ESR 4.1 Redhead's reply 4.2 French and Ladyman's reply Replies Designed to Rescue the Ramsey-Sentence Approach 5.1 Zahar's reply 5.2 Cruse's reply 5.3 Melia and Saatsi's reply Replies that Argue that Some Structures/Relations are Privileged 6.1 A Carnapian reply 6.2 Votsis' reply 6.3 The Merrill/Lewis/Psillos reply Summary CiteULike Connotea Del.icio.us What's this? (shrink)

Peter Alldridge, Relocating Criminal Law Aldershot, England: Dartmouth Publishing Company, 2000, xxvi + 247 pp.

Included is a famous nineteenth-century debate about scientific reasoning between the hypothetico-deductivist William Whewell and the inductivist John Stuart Mill; and an account of the realism-antirealism dispute about unobservables in science, with a consideration of Perrin's argument for the existence of molecules in the early twentieth century.

The problem of value pluralism permeates modern political philosophy. Its presence can be felt even when it is not explicitly the central topic under investigation. Political thinkers such as Max Weber, Isaiah Berlin and Stuart Hampshire derive pessimistic, sometimes tragic, conclusions from their reflections upon pluralism."--Page 4 of cover.

Stuart Hampshire's political thought is an important but often overlooked contribution to contemporary debates concerning the nature and permanence of plural and conflicting values. In its combination of a pessimistic view of the limits of politics with a deep respect for pluralism and disagreement Hampshire's thought can be regarded as a significant version of 'the Liberalism of fear'. This is grounded in a belief that the inherited innocence of moral and political thinking has been undermined by our experience of (...) the horrors of the twentieth century. Hampshire's response is to propose a minimal form of proceduralism that contrasts with Rawls's political liberalism. Hampshire offers a criticism of the moralism that characterizes much modern political philosophy without advocating a stark realism. (shrink)

I consider and reject William Whewell's attack on the inductivism of Isaac Newton and John Stuart Mill, as well as John Norton's attack on any universal system of inductive rules. I also explain how a system of inductive rules of the sort proposed by Newton and Mill should be understood.

Modal functionalism is the view that talk about possible worlds should be construed as talk about fictional objects. The version of modal fictionalism originally presented by Gideon Rosen adopted a simple prefixing strategy for fictionalising possible worlds analyses of modal propositions. However, Stuart Brock and Rosen himself in a later article have independently advanced an objection that shows that the prefixing strategy cannot serve fictionalist purposes. In this paper we defend fictionalism about possible worlds by showing that there are (...) other strategies besides the prefixing strategy for fictionalising talk about possible worlds, and that these strategies are proof against the objection advanced by Brock and Rosen. (shrink)

This volume collects a wealth of articles covering a range of topics of practical concern in the field of ethics, including active and passive euthanasia, abortion, organ transplants, capital punishment, the consequences of human actions, slavery, overpopulation, the separate spheres of men and women, animal rights, and game theory and the nuclear arms race. The contributors are Thomas Nagel, David Hume, James Rachels, Judith Jarvis Thomson, Michael Tooley, John Harris, John Stuart Mill, Louis Pascal, Jonathan Glover, Derek Parfit, R.M. (...) Hare, Janet Radcliffe Richards, Peter Singer, and Nicholas Measor. (shrink)